Isoniazid (INH) can affect which vitamin in the client receiving antitubercular therapy?

Isoniazid (INH) can affect which vitamin in the client receiving antitubercular therapy?

• A. Vitamin B12
• B. Vitamin C
• C. Vitamin B6
• D. Vitamin D

Answer: (C)

Isoniazid can cause a functional deficiency of vitamin B6 (pyridoxine). The drug interacts with the active form of B6, pyridoxal phosphate, forming a complex that depletes B6 stores. Since B6 is a crucial cofactor for many enzymes involved in amino acid metabolism and neurotransmitter synthesis, its shortage leads to problems like peripheral neuropathy and, less commonly, sideroblastic anemia. Because of this risk, vitamin B6 is routinely given with isoniazid to help prevent neuropathy. Other vitamins listed aren’t specifically affected by isoniazid in standard TB therapy.

Isoniazid can cause a functional deficiency of vitamin B6 (pyridoxine). The drug interacts with the active form of B6, pyridoxal phosphate, forming a complex that depletes B6 stores. Since B6 is a crucial cofactor for many enzymes involved in amino acid metabolism and neurotransmitter synthesis, its shortage leads to problems like peripheral neuropathy and, less commonly, sideroblastic anemia. Because of this risk, vitamin B6 is routinely given with isoniazid to help prevent neuropathy. Other vitamins listed aren’t specifically affected by isoniazid in standard TB therapy.